HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

The upper panel shows a haemotoxylin- and eosin-stained, 6 μm-thick heart section from a mouse previously inoculated with the non-cardiovirulent group B coxsackievirus type 3, strain GA (CVB3/GA); despite replication in the heart, no myocarditis was induced. The lower panel shows typical myocarditis that occurs subsequent to inoculation with a cardiovirulent CVB3 strain. Mapping CVB3 genetics of cardiovirulence suggests a requirement for a specific secondary structure variation within the CVB3 5′ non-translated region (NTR), without which myocarditis cannot be induced in mice; this specific variation does not form in the CVB3/GA 5′ NTR RNA. Images courtesy Professor S. Tracy, Department of Pathology and Microbiology, UNMC, Omaha, NE 68198 USA. See the paper by Lee et al. in J Gen Virol, vol. 86, pp. 197--210.

[Table of Contents]