f The effect of body temperature and cell-mediated immunity on the growth of Mycobacterium marinum and Mycobacterium leprae in mice
- Authors: R. DENISE LANCASTER, M. J. COLSTON, G. R. F. HILSON, SHEILA M. TURNER*
- J. Med. Microbiol., November 1981 14: 493-500, doi: 10.1099/00222615-14-4-493
- Subject: Short Articles
- Published Online:
SUMMARY. Evidence is presented that the high susceptibility of armadillos to infection with Mycobacterium leprae cannot be explained solely in terms of body temperature because mutant mice maintained with a body temperature similar to that of armadillos do not become heavily infected with M. leprae. The depression of cell-mediated immunity accompanying the low body temperature is not sufficient to produce an overwhelming infection. The results obtained with M. marinum suggest that whereas lack of cell-mediated immunity or a low body temperature result in a moderately enhanced infection in the mouse a combination of both of these factors is required to produce an overwhelming infection involving the internal organs.
Present address: Department of Botany, University of Bristol.
© 1981 The Pathological Society of Great Britain and Ireland | Published by the Society for General Microbiology
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