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This Article Full Text (Papers in Press[PDF]) All Versions of this Article: jmm.0.010207-0v1 58/8/1092    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Chardin, H. Articles by Bouvet, A. PubMed PubMed Citation Articles by Chardin, H. Articles by Bouvet, A. Agricola Articles by Chardin, H. Articles by Bouvet, A.

Reduced susceptibility to amoxicillin of oral streptococci following amoxicillin exposure

¹ Universite Paris Descartes;

² AP-HP, Hopital A. Chenevier, Service d'Odontologie;

³ AP-HP, Hopital de l'Hotel-Dieu;

⁴ AP-HP, Hopital Europeen Georges Pompidou;

⁵ AP-HP, Hopital Pitie-Salpetriere

⁶ E-mail: helene.chardin{at}parisdescartes.fr

Received February 9, 2009
Accepted May 6, 2009

Background: Since antibiotic pressure often triggers bacterial resistance, the use of short duration therapies is increasingly recommended. The objective of the present study was to evaluate both the clinical efficiency and the impact on oral streptococci of a 3-day versus a 7-day amoxicillin therapy of odontogenic infection requiring tooth extraction.Methods: On day 0, patients were randomly assigned to either a 3-day or a 7-day amoxicillin treatment. The tooth was extracted on day 2 and the post-operative follow-up was done on day 9. Oral flora was collected on day 0, day 9 and day 30, and the susceptibility to amoxicillin of streptococci was determined.Results: The results showed that treatments of 3 days or 7 days of amoxicillin had a similar clinical efficiency, but also induced similar selection of oral streptococci with reduced susceptibility to amoxicillin.Conclusion: This study suggests that the selection of strains with reduced susceptibility to amoxicillin is a rapid phenomenon, appearing even in short duration therapies.