HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (Papers in Press[PDF]) All Versions of this Article: jmm.0.008797-0v1 58/7/963    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Deptula, A. Articles by Matewski, D. PubMed PubMed Citation Articles by Deptula, A. Articles by Matewski, D. Agricola Articles by Deptula, A. Articles by Matewski, D.

Toxin A-producing Clostridium difficile as an aetiologic factor of post-traumatic wound infection

Aleksander Deptula¹, Ewa Kruszyska, Agnieszka Mikucka, Eugenia Gospodarek, Krzysztof Olszewski, Jacek Kruczyski and Dariusz Matewski

Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz

¹ E-mail: deptul{at}o2.pl

Received December 15, 2008
Accepted March 10, 2009

Clostridium difficile is a well known cause of hospital-acquired infection such as antibiotic associated diarrhoea or pseudomembranous colitis. Extraintestinal infections caused by this pathogen are described rarely. A case of post-traumatic wound infection in immunocompetent, young and otherwise healthy trauma patient caused by C. difficile is reported. A 31-years old female, a car accident victim, was admitted to the hospital because of polytrauma after open reduction and internal fixation of the supracondylar femoral fracture by means of DCS system a purulent fistula occurred. The microbiological examination of the pus revealed C. difficile as a single aetiologic factor of this infection. The empirical antibiotic treatment with cefazoline and metronidazole had been administered right after the surgery, but was found to be ineffective. The strain isolated from the patient was sensitive to most antimicrobials except from clindamycin and amoxicillin/clavulanic acid had been chosen for the guided therapy. Such treatment combined with the removal of DCS system brought desirable effect.