J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published online ahead of print on 15 June 2009 as doi:10.1099/jmm.0.008052-0
Journal of Medical Microbiology 2009;58:1074.

J Med Microbiol (2009), DOI: 10.1099/jmm.0.008052-0
© 2009 Society for General Microbiology
This Article
Right arrow Full Text (Papers in Press[PDF])
Right arrow All Versions of this Article:
jmm.0.008052-0v1
58/8/1074    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Guo, N.
Right arrow Articles by Yu, L.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guo, N.
Right arrow Articles by Yu, L.
Agricola
Right arrow Articles by Guo, N.
Right arrow Articles by Yu, L.

Antifungal activity of thymol against clinical isolates of fluconazole-resistant Candida albicans

Na Guo1, Jingbo Liu2, Xiuping Wu3, Xingming Bi1, Rizeng Meng4, Xuelin Wang3, Hua Xiang1, Xuming Deng3 and Lu Yu3,5

1 College of Animal Science and Veterinary Medicine, Jilin University;

2 Department of Food Science, Faculty of Agriculture, Jilin University;

3 Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Animal Science;

4 Jilin Enrty-exit Inspection And Quarantine Bureau

5 E-mail: yulu225{at}126.com

Received November 16, 2008
Accepted April 15, 2009

Thymol (THY) was found to show in vitro antifungal activity against 24 fluconazole (FLC)- resistant and 12 FLC- susceptible clinical isolates of Candida albicans (C. albicans), standard strain ATCC 10231 and one experimentally induced FLC- resistant C. albicans S-1. In addition, synergism was observed for clinical isolates of C. albicans in combinations of THY-FLC and THY-amphotericin B (AMB) evaluated by the checkerboard microdilution method. The interaction intensity was determined by spectrophotometric methods of the checkerboard assay, and the nature of the interactions was assessed using two non-parametric approaches (fractional inhibitory concentration index (FICI) and {Delta}E models). The interaction between THY-FLC or THY-AMB in FLC- resistant and - susceptible strains of C. albicans showed high percentages of synergism by the FICI method and the {Delta}E method. The {Delta}E model gave results consistent with FICI, and no antagonistic action was observed in strains tested.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2009 Society for General Microbiology.