HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by WOLLE, K. Articles by KÖNIG, W. Search for Related Content PubMed PubMed Citation Articles by WOLLE, K. Articles by KÖNIG, W. Agricola Articles by WOLLE, K. Articles by KÖNIG, W.

Antibiotic susceptibility of Helicobacter pylori in Germany: stable primary resistance from 1995 to 2000

Institute of Medical Microbiology and *Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University Magdeburg, Germany

Corresponding author: Professor Dr W. König (e-mail: wolfgang.koenig{at}medizin.unimagdeburg.de).

Received 13 Nov. 2001; revised version received 29 Jan 2002; accepted 14 March 2002.

Abstract

The issue of antibiotic resistance in Helicobacter pylori is of particular concern and has become an important factor leading to eradication failure. This paper reports the prevalence of primary resistance to clarithromycin, amoxicillin, metronidazole and tetracycline among H. pylori isolates in the north-eastern part of Germany. A total of 1644 clinical H. pylori isolates was investigated over a period of 6 years from 1995 to 2000. The MICs were determined by the Etest. The overall rate of primary resistance was 26.2% for metronidazole and 2.2% for clarithromycin. No significant changes in the resistance rates during the period of investigation were observed. No isolate was resistant to amoxicillin or tetracycline. PCR-RFLP analysis for the detection of point mutations associated with clarithromycin resistance was performed with 36 H. pylori isolates. The A G transition mutation at position 2143 was detected in 19 H. pylori isolates (52.8%), whereas the mutation at position 2142 was found in 13 isolates (36.1%).

This article has been cited by other articles:

				S Koletzko, F Richy, P Bontems, J Crone, N Kalach, M L Monteiro, F Gottrand, D Celinska-Cedro, E Roma-Giannikou, G Orderda, et al. Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe Gut, December 1, 2006; 55(12): 1711 - 1716. [Abstract] [Full Text] [PDF]

				N. C Elviss, R. J Owen, A. Breathnach, C. Palmer, and N. Shetty Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000 J. Med. Microbiol., June 1, 2005; 54(6): 567 - 574. [Abstract] [Full Text] [PDF]

				F Megraud H pylori antibiotic resistance: prevalence, importance, and advances in testing Gut, September 1, 2004; 53(9): 1374 - 1384. [Full Text] [PDF]

				E. A.B. Cameron, K. U. Powell, L. Baldwin, P. Jones, G. D. Bell, and S. G.J. Williams Helicobacter pylori: antibiotic resistance and eradication rates in Suffolk, UK, 1991-2001 J. Med. Microbiol., June 1, 2004; 53(6): 535 - 538. [Abstract] [Full Text] [PDF]