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J. Med. Microbiol. -- Vol. 51 (2002), 567-608
© 2002 Society for General Microbiology
ISSN 0022-2615

ANTIMICROBIAL AGENTS AND RESISTANCE

Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils

A. SMITH-PALMER*, J. STEWART{dagger} and L. FYFE*

*Department of Dietetics, Nutrition and Biological Sciences, Queen Margaret University College, Clerwood Terrace, Edinburgh EH12 8TS and {dagger}Department of Medical Microbiology, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG

Corresponding author: Dr L. Fyfe. *Present address: Department of Biological Sciences, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS.

Received 15 March 2001; revised version accepted 22 Oct. 2001.

Abstract

Successful infection by Listeria monocytogenes is dependent upon a range of bacterial extracellular proteins including a cytolysin termed listeriolysin O and phosphatidylcholine-specific phospholipase C. Five plant essential oils – bay, clove, cinnamon, nutmeg and thyme – significantly reduced the production of listeriolysin O by L. monocytogenes. The greatest change was observed after culture with oil of thyme, which reduced haemolysis to 52.1 haemolytic units (HU)/ml compared with 99.85muHU/ml observed with the control. Oil of clove was the only oil that also significantly reduced phosphatidylcholine-specific phospholipase C activity. These changes were observed despite the oils causing no change to the final bacterial concentration or total extracellular protein concentration.






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