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Interleukin-8 induction and adhesion of the coccoid form of Helicobacter pylori

TAKAKO OSAKI, HIROYUKI YAMAGUCHI, HARUHIKO TAGUCHI, MINORU FUKADA^*, HAYATO KAWAKAMI, HIROSHI HIRANO and SHIGERU KAMIYA

Division of Medical Microbiology, Department of Infectious Diseases, *Laboratory for Electron Microscopy and 2nd Department of Anatomy, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo, Japan

Corresponding author: Dr T. Osaki (e-mail: osaki{at}kyorin-u.ac.jp

Received 17 April 2001; revised version accepted 22 Sept. 2001.

Abstract

To determine the pathological significance of the coccoid form of Helicobacter pylori, its adhesion to and induction of secretion of interleukin-8 (IL-8) by gastric epithelial (MKN45) cells were studied. By flow cytometry, the adhesion of the coccoid form to MKN45 cells was significantly lower than that of the helical form. The monoclonal antibody A20 recognising lipopolysaccharide of H. pylori inhibited the adhesion of the coccoid form to MKN45 cells as much as that of the helical form. There was significantly lower induction of IL-8 secretion by MKN45 cells exposed to the coccoid form (two of four strains) as compared with the helical form.

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