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Prevalence of the carbapenemase gene (cfiA) among clinical and normal flora isolates of Bacteroides species in Hungary

Department of Clinical Microbiology, Albert Szent-Györgyi Medical University, Szeged, Hungary

Corresponding author: Dr E. Nagy (e-mail: NAGYE@ mlab.szote.U-Szeged.Hu).

Received 14 Sept. 1999; revised version received 28 Oct. 1999; accepted 12 Nov. 1999.

Abstract

The carbapenemase gene (cfiA) was detected in 4 (5.7%) of 70 clinical isolates of Bacteroides fragilis from different parts of Hungary. Among 24 other Bacteroides species isolated from infectious processes or from normal faecal flora, none was cfiA-positive. The MIC of imipenem and meropenem for all cfiA-positive B. fragilis isolates was 0.25 mg/L, but 17% of the B. fragilis and 46% of the non-fragilis Bacteroides isolates exhibited reduced susceptibility to imipenem (MICs 0.5–2 mg/L). Only one of these isolates produced increased levels of ß-lactamase. No difference was observed in the outer-membrane proteins of B. fragilis isolates that harboured the cfiA gene and those with reduced susceptibility to imipenem.

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