J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ADAM, B.
Right arrow Articles by DOUGLAS, L. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ADAM, B.
Right arrow Articles by DOUGLAS, L. J.
Agricola
Right arrow Articles by ADAM, B.
Right arrow Articles by DOUGLAS, L. J.
J. Med. Microbiol. -- Vol. 51 (2002), 344-349
© 2002 Society for General Microbiology
ISSN 0022-2615

ANTIMICROBIAL AGENTS

Mixed species biofilms of Candida albicans and Staphylococcus epidermidis

BERIT ADAM, GEORGE S. BAILLIE and L. JULIA DOUGLAS

Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK

Corresponding author: Dr L. J. Douglas (e-mail: J.Douglas{at}bio.gla.ac.uk).

Received 4 Sept. 2001; revised version accepted 28 Oct. 2001.

Abstract

A simple catheter disk model system was used to study the development in vitro of mixed species biofilms of Candida albicans and Staphylococcus epidermidis, two organisms commonly found in catheter-associated infections. Two strains of S. epidermidis were used: a slime-producing wild type (strain RP62A) and a slime-negative mutant (strain M7). In mixed fungal-bacterial biofilms, both staphylococcal strains showed extensive interactions with C. albicans. The susceptibility of 48-h biofilms to fluconazole, vancomycin and mixtures of the drugs was determined colorimetrically. The results indicated that the extracellular polymer produced by S. epidermidis RP62A could inhibit fluconazole penetration in mixed fungal-bacterial biofilms. Conversely, the presence of C. albicans in a biofilm appeared to protect the slime-negative staphylococcus against vancomycin. Overall, the findings suggest that fungal cells can modulate the action of antibiotics, and that bacteria can affect antifungal activity in mixed fungal-bacterial biofilms.




This article has been cited by other articles:


Home page
 Appl. Environ. Microbiol.Home page
T. Kawarai, S. Furukawa, H. Ogihara, and M. Yamasaki
Mixed-Species Biofilm Formation by Lactic Acid Bacteria and Rice Wine Yeasts
Appl. Envir. Microbiol., July 15, 2007; 73(14): 4673 - 4676.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. P. Venkatesh, D. Pham, M. Fein, L. Kong, and L. E. Weisman
Neonatal Coinfection Model of Coagulase-Negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: Fluconazole Prophylaxis Enhances Survival and Growth
Antimicrob. Agents Chemother., April 1, 2007; 51(4): 1240 - 1245.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
M. A. Al-Fattani and L. J. Douglas
Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance.
J. Med. Microbiol., August 1, 2006; 55(Pt 8): 999 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. A. Jabra-Rizk, T. F. Meiller, C. E. James, and M. E. Shirtliff
Effect of Farnesol on Staphylococcus aureus Biofilm Formation and Antimicrobial Susceptibility.
Antimicrob. Agents Chemother., April 1, 2006; 50(4): 1463 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
R. K. Pettit, C. A. Weber, M. J. Kean, H. Hoffmann, G. R. Pettit, R. Tan, K. S. Franks, and M. L. Horton
Microplate Alamar Blue Assay for Staphylococcus epidermidis Biofilm Susceptibility Testing
Antimicrob. Agents Chemother., July 1, 2005; 49(7): 2612 - 2617.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
G. Ramage, S. P. Saville, D. P. Thomas, and J. L. Lopez-Ribot
Candida Biofilms: an Update
Eukaryot. Cell, April 1, 2005; 4(4): 633 - 638.
[Full Text] [PDF]

Home page
 J Med MicrobiolHome page
M. Theraud, Y. Bedouin, C. Guiguen, and J. -P. Gangneux
Efficacy of antiseptics and disinfectants on clinical and environmental yeast isolates in planktonic and biofilm conditions
J. Med. Microbiol., October 1, 2004; 53(10): 1013 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. A. Al-Fattani and L. J. Douglas
Penetration of Candida Biofilms by Antifungal Agents
Antimicrob. Agents Chemother., September 1, 2004; 48(9): 3291 - 3297.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
D. Kaufman and K. D. Fairchild
Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants
Clin. Microbiol. Rev., July 1, 2004; 17(3): 638 - 680.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
X. Li, Z. Yan, and J. Xu
Quantitative variation of biofilms among strains in natural populations of Candida albicans
Microbiology, February 1, 2003; 149(2): 353 - 362.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2002 Society for General Microbiology.