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Published online ahead of print on 13 August 2009 as doi:10.1099/jmm.0.013912-0
Journal of Medical Microbiology 2009;58:1582.

J Med Microbiol (2009), DOI: 10.1099/jmm.0.013912-0
© 2009 Society for General Microbiology
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Constitutive expression of the ileS-2 gene responsible for high-level mupirocin resistance in Staphylococcus aureus

Naira Elane Moreira de Oliveira1, Elisa d'Avila Costa Cavalcanti2, Marinella Silva Laport1, Maria do Carmo de Freire Bastos1 and Marcia Giambiagi-deMarval1,3

1 Instituto de Microbiologia Prof. Paulo de Goes;

2 Instituto de Quimica - UFRJ

3 E-mail: marciagm{at}micro.ufrj.br

Received June 26, 2009
Accepted August 8, 2009

Mupirocin is a topical antimicrobial agent which is used for the treatment of skin and postoperative wound infections, and the prevention of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). However, prevalence of mupirocin resistance in S. aureus, particularly in MRSA, has increased. High-level mupirocin resistance, with MICs ≥512 µg ml-1, is mediated by the ileS-2 gene which is located on conjugative plasmids. In the present study, we investigated whether mupirocin influences the expression of the ileS-2 gene, responsible for high-level mupirocin resistance, and we present some evidences that this gene is not upregulated but constitutively expressed in S. aureus.






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