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Subinhibitory concentrations of moxifloxacin decrease adhesion and biofilm formation of Stenotrophomonas maltophilia from cystic fibrosis

¹ University of Chieti-Pescara, Italy;

² Spirito Santo Hospital of Pescara, Italy;

³ Bambin Gesu Pediatric Hospital of Rome, Italy

⁴ E-mail: gdibonaventura{at}unich.it

Received April 23, 2009
Accepted September 16, 2009

Stenotrophomonas maltophilia is an emerging nosocomial bacterial pathogen which is currently isolated with increasing frequency from the airways of cystic fibrosis (CF) patients. We evaluated the effect of subinhibitory concentrations of moxifloxacin against adhesion, biofilm formation, and cell-surface hydrophobicity of two strains of Stenotrophomonas maltophilia isolated from CF patients. Adhesion and biofilm formation assays were carried out on polystyrene and quantified by colony counts. CSH was determined by adhesion to n-hexadecane test. Moxifloxacin at 0.03x and 0.06xMIC caused a significant decrease of adhesion and biofilm formation by both strains tested. A significant reduction of the cell-surface hydrophobicity following exposure to sub-MICs of moxifloxacin was observed for one strain only. Results of the present study provided an additional rationale for the use of moxifloxacin in CF patients and, more generally, in biofilm-related infections involving S. maltophilia.