J Med Microbiol Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published online ahead of print on 20 August 2009 as doi:10.1099/jmm.0.010033-0
Journal of Medical Microbiology 2009;58:1585.

J Med Microbiol (2009), DOI: 10.1099/jmm.0.010033-0
© 2009 Society for General Microbiology
This Article
Right arrow Full Text (Papers in Press[PDF])
Right arrow All Versions of this Article:
jmm.0.010033-0v1
58/12/1585    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Minh Vien, L. T.
Right arrow Articles by Schultsz, C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Minh Vien, L. T.
Right arrow Articles by Schultsz, C.
Agricola
Right arrow Articles by Minh Vien, L. T.
Right arrow Articles by Schultsz, C.

High Prevalence of Plasmid-mediated Quinolone Resistance Determinants in Commensal Enterobacteriaceae in Ho Chi Minh City, Viet Nam

Le Thi Minh Vien1, Stephen Baker1, Le Thi Phuong Thao1, Le Thi Phuong Tu1, Cao Thu Thuy1, Tran Thi Thu Nga1, Nguyen Van Minh Hoang1, James Campbell1, Lam Thi Minh Yen2, Nguyen Trong Hieu3, Nguyen Van Vinh Chau2, Jeremy Farrar1 and Constance Schultsz4,5

1 Oxford University Clinical Research Unit, Hospital for Tropical Diseases;

2 Hospital for Tropical Diseases;

3 Hung Vuong Hospital;

4 AMC-CPCD

5 E-mail: schultsz{at}gmail.com

Received February 4, 2009
Accepted August 14, 2009

Antimicrobial resistant pathogenic Enterobacteriaceae are a well defined global problem. We hypothesized that one of the main reservoirs of dissemination of antimicrobial resistance genes in Viet Nam is non-pathogenic intestinal flora. We sought to isolate antimicrobial resistant organisms from hospitalized patients and non-hospitalised healthy individuals in Ho Chi Minh City. Our study identified substantial faecal carriage of gentamicin, ceftazidime and nalidixic acid resistant Enterobacteriaceae in both hospitalized patients and non-hospitalised healthy individuals. We identified a high prevalence of quinolone resistance determinants, particularly the qnrS gene, in both the community and the hospital associated strains. Furthermore, our results demonstrated that a combination of quinolone resistance determinants can confer resistance to nalidixic acid and ciprofloxacin, even in the apparent absence of additional chromosomal resistance mutations in wild type strains and laboratory strains with transferred plasmids. These data suggests that intestinal commensal organisms are a significant reservoir for the dissemination of plasmid-mediated quinolone resistance in Ho Chi Minh City.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2009 Society for General Microbiology.