J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duguid, J. P.
Right arrow Articles by Wheater, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duguid, J. P.
Right arrow Articles by Wheater, D. W.
Agricola
Right arrow Articles by Duguid, J. P.
Right arrow Articles by Wheater, D. W.

The Journal of Medical Microbiology, Vol 9, Issue 4 459-473, Copyright © 1976 by Society for General Microbiology

JOURNAL ARTICLE

Fimbriae and infectivity in Salmonella typhimurium

J. P. Duguid, M. R. Darekar and D. W. Wheater

A genotypically non-fimbriate (Fim-) strain of Salmonella typhimurium and a genotypically fimbriate (Fim+) strain derived from it by spontaneous mutation were compared for pathogenicity in mice. The two strains caused similar numbers of infections and deaths in groups of mice challenged by intraperitoneal inoculation, and nearly similar numbers in groups challenged by inoculation on to the conjunctiva, but the Fim+ strain caused many more infections (plus 26%) and deaths (plus 40%) than the Fim- strain when the inoculation was by mouth. Faecal cultures were made at intervals up to 120 days in the mice surviving after oral or conjunctival challenge and S. typhimurium was isolated more commonly from the animals challenged with the Fim+ strain (906 isolations from 384 animals infected out of 877 challenged) than from those challenged with the Fim- strain (614 isolations from 341 animals infected out of 877 challenged). The greater opportunity for faecal dissemination enjoyed by Fim+ bacteria may account for the preponderance of Fim+ over Fim- strains of S. typhimurium found in mammalian sources.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
E. H. Weening, J. D. Barker, M. C. Laarakker, A. D. Humphries, R. M. Tsolis, and A. J. Baumler
The Salmonella enterica Serotype Typhimurium lpf, bcf, stb, stc, std, and sth Fimbrial Operons Are Required for Intestinal Persistence in Mice
Infect. Immun., June 1, 2005; 73(6): 3358 - 3366.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. Althouse, S. Patterson, P. Fedorka-Cray, and R. E. Isaacson
Type 1 Fimbriae of Salmonella enterica Serovar Typhimurium Bind to Enterocytes and Contribute to Colonization of Swine In Vivo
Infect. Immun., November 1, 2003; 71(11): 6446 - 6452.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
P. J. NAUGHTON, G. GRANT, S. BARDOCZ, E. ALLEN-VERCOE, M. J. WOODWARD, and A. PUSZTAI
Expression of type 1 fimbriae (SEF 21) of Salmonella enterica serotype Enteritidis in the early colonisation of the rat intestine
J. Med. Microbiol., February 1, 2001; 50(2): 191 - 197.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Thankavel, A. H. Shah, M. S. Cohen, T. Ikeda, R. G. Lorenz, R. Curtiss III, and S. N. Abraham
Molecular Basis for the Enterocyte Tropism Exhibited by Salmonella typhimurium Type 1 Fimbriae
J. Biol. Chem., February 26, 1999; 274(9): 5797 - 5809.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. W. M. van der Velden, A. J. Baumler, R. M. Tsolis, and F. Heffron
Multiple Fimbrial Adhesins Are Required for Full Virulence of Salmonella typhimurium in Mice
Infect. Immun., June 1, 1998; 66(6): 2803 - 2808.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1976 Society for General Microbiology.