J Med Microbiol Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Russell, R. J.
Right arrow Articles by Arbuthnott, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Russell, R. J.
Right arrow Articles by Arbuthnott, J. P.
Agricola
Right arrow Articles by Russell, R. J.
Right arrow Articles by Arbuthnott, J. P.

The Journal of Medical Microbiology, Vol 9, Issue 4 433-439, Copyright © 1976 by Society for General Microbiology

JOURNAL ARTICLE

Effects of staphylococcal products on locomotion and chemotaxis of human blood neutrophils and monocytes

R. J. Russell, P. C. Wilkinson, R. J. McInroy, S. McKay, A. C. McCartney and J. P. Arbuthnott

The effects of staphylococcal products as chemo-attractants for human blood neutrophils and monocytes and as inhibitors of locomotion of these cells were studied with bacterial cells, culture filtrates and isoelectrically focused fractions from culture filtrates of nine strains of Staphylococcus aureus. Little direct chemotactic activity of staphylococcal products for neutrophils was observed, although a chloroform-soluble extract of the whole organisms contained such activity. The major chemotactic effect of staphylococci for neutrophils was indirect, i.e., generated when the organisms or their products were incubated with plasma, perhaps due to activation of complement. In contrast, direct chemotactic activity for monocytes was found in a large number of staphylococcal fractions. Staphylococci also produced inhibitors of locomotion of both neutrophils and monocytes. Isoelectric focusing showed more fractions inhibitory for neutrophils than for monocytes. Some of the inhibitors could be identified. Staphylococcal alpha-toxin inhibited migration of both neutrophils and monocytes. Sphingomyelinase C (beta toxin) inhibited migration of monocytes but not of neutrophils. Leucocidin-rich strains were strongly active as inhibitors of neutrophil locomotion but less so as inhibitors of monocyte locomotion.


This article has been cited by other articles:


Home page
 J. Exp. Med.Home page
C. J.C. de Haas, K. E. Veldkamp, A. Peschel, F. Weerkamp, W. J.B. Van Wamel, E. C.J.M. Heezius, M. J.J.G. Poppelier, K. P.M. Van Kessel, and J. A.G. van Strijp
Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent
J. Exp. Med., March 1, 2004; 199(5): 687 - 695.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1976 Society for General Microbiology.