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The Journal of Medical Microbiology, Vol 8, Issue 4 565-569, Copyright © 1975 by Society for General Microbiology

JOURNAL ARTICLE

Transmission of human rotaviruses to gnotobiotic piglets

J. C. Bridger, G. N. Woode, J. M. Jones, T. H. Flewett, A. S. Bryden and H. Davies

Faecal filtrates containing rotavirus particles, from children with acute infectious diarrhoea, were inoculated intranasally into gnotobiotic piglets. The piglets developed no symptoms, but birus was readily found by electron microscopy in their faeces during three serial passages. Among 11 piglets tested 3 weeks after inoculation of virus, all had developed fluorescent antibodies against tissue-culture-adapted calf rotavirus but only two had neutralising antibody. Growth of human rotavirus did not occur in either normal or "nude", thymus-deficient suckling mice.


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M. Ciarlet, M. K. Estes, and M. E. Conner
Simian rhesus rotavirus is a unique heterologous (non-lapine) rotavirus strain capable of productive replication and horizontal transmission in rabbits
J. Gen. Virol., May 1, 2000; 81(5): 1237 - 1249.
[Abstract] [Full Text]


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