The Journal of Medical Microbiology, Vol 8, Issue 3 405-411, Copyright © 1975 by Society for General Microbiology

JOURNAL ARTICLE

Adhesion of enteropathogenic Escherichia coli to pig intestinal brush borders: the existence of two pig phenotypes

R. Sellwood, R. A. Gibbons, G. W. Jones and J. M. Rutter

An in-vitro test that demonstrates adhesion of K88-positive Escherichia coli to brush borders prepared from the small intestine of the pig is described. K88-positive E. coli adhered to the brush borders from some pigs ("positive" pigs) but not others ("negative" pigs). The sires of the pigs tested could be placed into two groups, namely, those that sired only "positive" piglets, and those that sired a mixture of "positive" and "negative" piglets. The incidence of the two phenotypes in litters indicated that "positive" and "negative" piglets arose as a result of simple Mendelian inheritance. It is suggested that "negative" pigs could be bred and that they might have a natural resistance to neonatal infection with K88-positive E. coli.

This article has been cited by other articles:

				W. Zhang, E. M. Berberov, J. Freeling, D. He, R. A. Moxley, and D. H. Francis Significance of heat-stable and heat-labile enterotoxins in porcine colibacillosis in an additive model for pathogenicity studies. Infect. Immun., June 1, 2006; 74(6): 3107 - 3114. [Abstract] [Full Text] [PDF]

				T. N. Do, I. Wilkie, S. J. Driesen, V. A. Fahy, and D. J. Trott Pathogenicity of Vietnamese Enterotoxigenic Escherichia coli Strains in Colostrum-deprived One-day-old Piglets. Vet. Pathol., February 1, 2006; 43(2): 150 - 160. [Abstract] [Full Text] [PDF]

				P. A. Grange, A. K. Erickson, S. B. Levery, and D. H. Francis Identification of an Intestinal Neutral Glycosphingolipid as a Phenotype-Specific Receptor for the K88ad Fimbrial Adhesin of Escherichia coli Infect. Immun., January 1, 1999; 67(1): 165 - 172. [Abstract] [Full Text] [PDF]

				D. H. Francis, P. A. Grange, D. H. Zeman, D. R. Baker, R. Sun, and A. K. Erickson Expression of Mucin-Type Glycoprotein K88 Receptors Strongly Correlates with Piglet Susceptibility to K88+ Enterotoxigenic Escherichia coli, but Adhesion of This Bacterium to Brush Borders Does Not Infect. Immun., September 1, 1998; 66(9): 4050 - 4055. [Abstract] [Full Text] [PDF]

				D S Chandler and T L Mynott Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli Gut, August 1, 1998; 43(2): 196 - 202. [Abstract] [Full Text] [PDF]

				P. A. Grange, A. K. Erickson, T. J. Anderson, and D. H. Francis Characterization of the Carbohydrate Moiety of Intestinal Mucin-Type Sialoglycoprotein Receptors for the K88ac Fimbrial Adhesin of Escherichia coli Infect. Immun., April 1, 1998; 66(4): 1613 - 1621. [Abstract] [Full Text] [PDF]