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Effects of Oral Inoculation of Candida Albicans in Tetracycline-Treated Rats

Departments of Bacteriology and Oral Medicine, University of Manchester

Received August 18, 1972
Accepted August 22, 1972

After being given tetracycline in drinking water (0·1 per cent.) for 5 days, rats were inoculated orally with Candida albicans on three occasions at 2-day intervals. Immediately after the first inoculation, the concentration of tetracycline in the water was reduced to 0·01 per cent. and this was maintained for the next 28 days. The rats' mouths were regularly colonised by C. albicans, the organism being recoverable throughout the experiment. Histological examination showed the organism in the tissues in 75 per cent. of the animals. Infection of the dorsal surface of the tongue produced a striking change in the histological appearance of the lingual epithelium, reminiscent of that found in candidal leukoplakia in man.

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