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J Med Microbiol 58 (2009), 1203-1206; DOI: 10.1099/jmm.0.008268-0
© 2009 Society for General Microbiology
ISSN 0022-2615

In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms

Robin K. Pettit1, Christine A. Weber1,{dagger}, Stacey B. Lawrence1, George R. Pettit1, Melissa J. Kean1 and Gary D. Cage2

1 Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA

2 Phoenix Children's Hospital, Phoenix, AZ 85016, USA

Correspondence
Robin K. Pettit
robin.pettit{at}asu.edu

Received November 25, 2008
Accepted May 27, 2009

The alarming spread of multiple drug resistance in Staphylococcus aureus, combined with the frequent occurrence of S. aureus and Staphylococcus epidermidis in biofilm-type infections, indicates a growing need for new therapies. The experimental steroidal amide anprocide [3β-acetoxy-17β-(L-prolyl)amino-5{alpha}-androstane] significantly reduced c.f.u. ml–1 per suture (P <0.0001) in a murine model of topical S. aureus infection. In chequerboard assays with planktonic-grown S. aureus and S. epidermidis, anprocide was synergistic with bacitracin, oxacillin, clindamycin or ceftriaxone. Anprocide was also synergistic in combination with bacitracin or oxacillin against some isolates of biofilm-grown S. aureus and S. epidermidis.

{dagger}Present address: Department of Pharmacy, Ludwig Maximilians University, Munich, Germany.






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