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J Med Microbiol 58 (2009), 1074-1079; DOI: 10.1099/jmm.0.008052-0
© 2009 Society for General Microbiology
ISSN 0022-2615

Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans

Na Guo1,2,{dagger}, Jingbo Liu2,{dagger}, Xiuping Wu1, Xingming Bi1, Rizeng Meng3, Xuelin Wang1, Hua Xiang1, Xuming Deng1 and Lu Yu1

1 Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, PR China

2 Laboratory of Nutrition and Functional Food, Jilin University, Changchun 130062, PR China

3 Jilin Entry–Exit Inspection and Quarantine Bureau, Changchun 130062, PR China

Correspondence
Xuming Deng
xumingdeng{at}jluhp.edu.cn
Lu Yu
yulu225{at}126.com

Received November 16, 2008
Accepted April 15, 2009

Thymol (THY) was found to have in vitro antifungal activity against 24 fluconazole (FLC)-resistant and 12 FLC-susceptible clinical isolates of Candida albicans, standard strain ATCC 10231 and one experimentally induced FLC-resistant C. albicans S-1. In addition, synergism was observed for clinical isolates of C. albicans with combinations of THY–FLC and THY–amphotericin B (AMB) evaluated by the chequerboard microdilution method. The interaction intensity was determined by spectrophotometry for the chequerboard assay, and the nature of the interactions was assessed using two non-parametric approaches [fractional inhibitory concentration index (FICI) and {Delta}E models]. The interaction between THY–FLC or THY–AMB in FLC-resistant and -susceptible strains of C. albicans showed a high percentage of synergism by the FICI method and the {Delta}E method. The {Delta}E model gave results consistent with FICI, and no antagonistic action was observed in the strains tested.

{dagger}These authors contributed equally to this work.






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