J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jmm.0.008128-0v1
58/7/923    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Thwaite, J. E.
Right arrow Articles by Atkins, H. S.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thwaite, J. E.
Right arrow Articles by Atkins, H. S.
Agricola
Right arrow Articles by Thwaite, J. E.
Right arrow Articles by Atkins, H. S.
J Med Microbiol 58 (2009), 923-929; DOI: 10.1099/jmm.0.008128-0
© 2009 Society for General Microbiology
ISSN 0022-2615

The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains

Joanne E. Thwaite1, Suzanne Humphrey1, Marc A. Fox1, Victoria L. Savage1, Thomas R. Laws1, David O. Ulaeto1, Richard W. Titball2 and Helen S. Atkins1

1 Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK

2 School of Biosciences, Geoffrey Pope Building, University of Exeter, Exeter EX4 4QD, UK

Correspondence
Helen S. Atkins
hsatkins{at}dstl.gov.uk

Received November 19, 2008
Accepted March 11, 2009

This study was undertaken to determine the antibacterial activity of eight cationic antimicrobial peptides towards strains of genomovars I–V of the Burkholderia cepacia complex (Bcc) in time–kill assays. All but one of the peptides failed to show activity against the panel of test strains. The exception was magainin II, a 23 aa peptide isolated from the epidermis of the African clawed frog, Xenopus laevis, which exhibited significant bactericidal activity for Bcc genomovars most frequently associated with lung infection of patients with cystic fibrosis. In vitro studies indicated that magainin II protected a human bronchial epithelial cell line (BEAS-2B) from killing by Bcc and suggest that this peptide may have therapeutic potential against these organisms.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2009 Society for General Microbiology.