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J Med Microbiol 58 (2009), 826-828; DOI: 10.1099/jmm.0.008060-0
© 2009 Society for General Microbiology
ISSN 0022-2615

Clostridium perfringens β-toxin binding to vascular endothelial cells in a human case of enteritis necroticans

Julien Miclard1, Joop van Baarlen2, Marianne Wyder1, Benno Grabscheid1 and Horst Posthaus1

1 Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Switzerland

2 Laboratorium Pathologie Oost Nederland, Enschede, The Netherlands

Correspondence
Horst Posthaus
horst.posthaus{at}itpa.unibe.ch

Received November 17, 2008
Accepted February 6, 2009

Clostridium perfringens type C-induced enteritis necroticans is a rare but often fatal disease in humans. A consistent histopathological finding is an acute, deep necrosis of the small intestinal mucosa associated with acute vascular necrosis and massive haemorrhage in the lamina propria and submucosa. Retrospective immunohistochemical investigations of tissues from a diabetic adult who died of enteritis necroticans revealed endothelial localization of C. perfringens β-toxin in small intestinal lesions. Our results indicate that vascular necrosis might be induced by a direct interaction between C. perfringens β-toxin and endothelial cells and that targeted disruption of endothelial cells plays a role in the pathogenesis of enteritis necroticans.

Supplementary figures are available with the online version of this paper.






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