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J Med Microbiol 58 (2009), 521-525; DOI: 10.1099/jmm.0.004465-0
© 2009 Society for General Microbiology
ISSN 0022-2615

Case Report

Mediterranean spotted fever with encephalitis

Luis Aliaga1, Patricia Sánchez-Blázquez1, Javier Rodríguez-Granger2, Antonio Sampedro2, Miguel Orozco1 and Jorge Pastor3

1 Faculty of Medicine (University of Granada), Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, s/n, 18014 Granada, Spain

2 Service of Microbiology, Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, s/n, 18014 Granada, Spain

3 Service of Radiology, Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, s/n, 18014 Granada, Spain

Correspondence
Javier Rodríguez-Granger
javierm.rodriguez.sspa{at}juntadeandalucia.es

Received July 1, 2008
Accepted December 30, 2008

Rickettsia conorii infection is endemic in the Mediterranean basin, where it is known as Mediterranean spotted fever, also known as Boutonneuse fever and Marseilles fever. We report the case of a 66-year-old diabetic man who presented a severe form of the disease, complicated by acute renal failure, thrombocytopenia and encephalitis. Diagnosis was confirmed by indirect immunofluorescence assay. Despite appropriate treatment, severe neurological sequelae have remained. Medical literature on encephalitis caused by R. conorii is also reviewed.

Abbreviations: CSF, cerebrospinal fluid; CT, computed tomography; MRI, magnetic resonance imaging; MSF, Mediterranean spotted fever.






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