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J Med Microbiol 58 (2009), 399-402; DOI: 10.1099/jmm.0.005504-0
© 2009 Society for General Microbiology
ISSN 0022-2615

Carriage of both the fnbA and fnbB genes and growth at 37 °C promote FnBP-mediated biofilm development in meticillin-resistant Staphylococcus aureus clinical isolates

Eoghan O'Neill1,2, Hilary Humphreys2 and James P. O'Gara1

1 UCD School of Biomolecular and Biomedical Science, Ardmore House, University College Dublin, Belfield, Dublin 4, Ireland

2 Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland

Correspondence
James P. O'Gara
jim.ogara{at}ucd.ie

Received July 30, 2008
Accepted December 6, 2008

The Staphylococcus aureus FnBPA and FnBPB proteins promote acid-induced biofilm accumulation. Meticillin-resistant S. aureus (MRSA) isolates from device-related infections with both fnbA and fnbB produced significantly more biofilm than isolates with either gene alone. Under mildly acidic growth conditions, FnBP-mediated biofilm and fnbA and fnbB transcript levels were substantially higher during growth at 37 °C than at 30 °C. Thus, in addition to a lowered pH, carriage of both fnbA and fnbB and growth at 37 °C promote MRSA biofilm development, further supporting a role for the FnBPA and FnBPB surface proteins in the pathogenesis of MRSA device-related infections.

Abbreviations: CC, clonal complex; MLST, multilocus sequence typing; MRSA, meticillin-resistant Staphylococcus aureus; MSSA, meticillin-sensitive S. aureus.






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