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Group B streptococcus colonization of pregnant women and their children observed on obstetric and neonatal wards of the University Hospital in Krakow, Poland

Magdalena Strus¹, Dorota Pawlik², Monika Brzychczy-Woch¹, Tomasz Gosiewski¹, Krzysztof Rytlewski³, Ryszard Lauterbach² and Piotr B. Heczko¹

¹ Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland

² Department of Neonatology, Jagiellonian University Medical College, Krakow, Poland

³ Department of Obstetrics, Gynaecology and Oncology, Chair of Obstetrics and Gynaecology, Jagiellonian University Medical College, Krakow, Poland

Correspondence
Piotr B. Heczko
mbheczko{at}cyf-kr.edu.pl

Received April 24, 2008
Accepted October 1, 2008

The study was arranged to assess the actual rates of colonization of pregnant women and their children with group B streptococcus (GBS) in a Polish university hospital. Resistance of these cocci to macrolides and clindamycin was also tested and routes of transmission of GBS were followed in some cases using molecular typing. Colonization with GBS was checked in 340 pregnant women living in the south-eastern region of Poland (Maopolska) in the years 2004–2006. Women with a complicated pregnancy were more often colonized than those with a normal pregnancy (20.0 % versus 17.2 %). Moreover, women with a complicated pregnancy were twice as often colonized with GBS strains with the MLS_B phenotype indicating resistance to macrolides and clindamycin. Regarding neonatal colonization by GBS, we found that neonates born from the colonized mothers with a complicated pregnancy were more often colonized with GBS than those from the mothers with a normal pregnancy (35 % versus 26.7 %). By molecular typing of the GBS strains isolated from mothers and their newborns we have been able to suggest the possibility of horizontal transmission of the strains from the hospital environment to newborns. Our results clearly indicate that rates of GBS colonization among pregnant women and neonates in a Polish university hospital have reached levels comparable to those reported in other European clinical centres.

Abbreviations: CDC, Centers for Disease Control and Prevention; FISH, fluorescence in situ hybridization; GBS, group B streptococcus; MLS_B, macrolide-lincosamide-streptogramin B; RAPD, random amplification of polymorphic DNA.