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J Med Microbiol 58 (2009), 1582-1584; DOI: 10.1099/jmm.0.013912-0
© 2009 Society for General Microbiology
ISSN 0022-2615

Constitutive expression of the ileS-2 gene responsible for high-level mupirocin resistance in Staphylococcus aureus

Naira Elane Moreira de Oliveira1,{dagger}, Elisa D'Avila Costa Cavalcanti2,{dagger}, Marinella Silva Laport1, Maria do Carmo de Freire Bastos1 and Marcia Giambiagi-deMarval1

1 Instituto de Microbiologia Prof. Paulo de Góes, Bloco I, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21491-590 Rio de Janeiro, RJ, Brazil

2 Instituto de Química, Bloco A, Centro de Tecnologia, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21491-590 Rio de Janeiro, RJ, Brazil

Correspondence
Marcia Giambiagi-deMarval
marciagm{at}micro.ufrj.br

Received June 26, 2009
Accepted August 8, 2009

Mupirocin is a topical antimicrobial agent that is used for the treatment of skin and postoperative wound infections, and the prevention of nasal carriage of meticillin-resistant Staphylococcus aureus (MRSA). However, the prevalence of mupirocin resistance in S. aureus, particularly in MRSA, has increased. High-level mupirocin resistance, with MICs ≥512 µg ml–1, is mediated by the ileS-2 gene, which is located on conjugative plasmids. In the present study, we investigated whether mupirocin influences the expression of the ileS-2 gene responsible for high-level mupirocin resistance, and we present some evidence that this gene is not upregulated but constitutively expressed in S. aureus.

{dagger}These authors contributed equally to this work.






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