J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
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J Med Microbiol 58 (2009), 1314-1321; DOI: 10.1099/jmm.0.009688-0
© 2009 Society for General Microbiology
ISSN 0022-2615

Two variants of staphylococcal cassette chromosome mec type IVA in community-associated meticillin-resistant Staphylococcus aureus strains in South Korea

Chulmin Park1, Hyun-Ho Shin1, Eun-Young Kwon1, Su-Mi Choi2, Si-Hyun Kim2, Sun Hee Park2, Jung-Hyun Choi2, Jin-Hong Yoo2, Dong-Gun Lee2 and Wan Shik Shin2

1 Catholic Research Institutes of Medical Science, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea

2 Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea

Correspondence
Dong-Gun Lee
symonlee{at}catholic.ac.kr

Received January 19, 2009
Accepted July 1, 2009

Meticillin-resistant Staphylococcus aureus (MRSA) strains harbouring staphylococcal cassette chromosome mec (SCCmec) type IVA are known to be more prevalent in South Korea than in other countries. Variations in the SCCmec IVA structure have been identified, including in sequence type (ST) 1 and ST72 strains. This study compared and investigated the genetic characteristics of two subtypes common in South Korea. Type IVA SCCmec of ST1 strains was characterized by type IV features with the linearized pUB110 at the junkyard (J) 3 region. However, that of ST72 strains carried a variant class B mec complex, ccrA2, with an identity of ~96 % and the linearized pUB110 at the J3 region. In SCCmec of ST72 strains, the organization of the class B variant and the J3 region may be more similar to that of type IA than to other types, but the ccr type and other J regions seemed to be derived from type IV. These genetic characteristics showed that type IVA appears to result from the dynamic genetic exchange and recombination of SCC DNA.

The GenBank/EMBL/DDBJ accession numbers for the complete SCCmec sequence of the ST72 clone and the mec element sequence of the ST1 clone are EU437549 and EU437550, respectively.






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