J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Malhotra, S.
Right arrow Articles by Hans, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Malhotra, S.
Right arrow Articles by Hans, C.
Agricola
Right arrow Articles by Malhotra, S.
Right arrow Articles by Hans, C.
J Med Microbiol 58 (2009), 146-150; DOI: 10.1099/jmm.0.005272-0
© 2009 Society for General Microbiology
ISSN 0022-2615

Case Report

Rhinocerebral zygomycosis with pulmonary aspergillosis in a non-HIV-infected patient: an unusual case report from India

Shalini Malhotra1, Shalini Duggal1, Nirmaljeet Kaur Bhatia1, Nishi Sharma2 and Charoo Hans1

1 Department of Microbiology, Dr Ram Manohar Lohia Hospital, New Delhi, India

2 Department of Otorhinolaryngology, Dr Ram Manohar Lohia Hospital, New Delhi, India

Correspondence
Shalini Malhotra
drshalinimalhotra{at}yahoo.com

Received July 27, 2008
Accepted September 29, 2008

Zygomycosis and aspergillosis are two serious opportunistic fungal infections that are commonly seen in immunocompromised patients. Since both these fungi invade vessels of the arterial system, an early and rapid diagnosis by direct examination of KOH mounts of the relevant clinical sample can confirm the diagnosis. Here, we present an unusual case of a diabetic patient who presented with nasal blockade and bleeding for 2 months, along with occasional haemoptysis for 15 days. On investigation, the patient was diagnosed with a case of rhinocerebral zygomycosis and was treated with amphotericin B (1 mg kg–1 day–1), which was subsequently replaced with liposomal amphotericin B (2 mg kg–1 day–1). However, the patient did not completely respond to therapy as haemoptysis continued. Further investigations revealed the presence of Aspergillus flavus in respiratory specimens. Thus, a final diagnosis of rhinocerebral zygomycosis with pulmonary aspergillosis in a non-HIV-infected patient was made, but due to infection of two vital sites by these fungi, the patient could not be saved.

Abbreviations: CT, computed tomography; SDA, Sabouraud's dextrose agar.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2009 Society for General Microbiology.