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J Med Microbiol 58 (2009), 101-104; DOI: 10.1099/jmm.0.003764-0
© 2009 Society for General Microbiology
ISSN 0022-2615

Adult invasive pneumococcal disease pre- and peri-pneumococcal conjugate vaccine introduction in a tertiary hospital in Singapore

Li-Yang Hsu1, See Weng Lui2, Jia Ling Lee2, Hazwany Md Mahrom Hedzlyn2, Debra Han-Lin Kong2, Suku Shameen2, Nur Puteri Mohammad Siti2, Wei Yu Tan2, Xin Yi Toh2, Tse-Yuen Koh2 and Tse-Hsien Koh3

1 Yong Loo Lin School of Medicine, National University of Singapore, Singapore

2 School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore

3 Singapore General Hospital, Singapore

Correspondence
Li-Yang Hsu
liyang_hsu{at}yahoo.com

Received May 27, 2008
Accepted September 4, 2008

Streptococcus pneumoniae isolates causing invasive disease at a large tertiary institute in Singapore from 2000 to 2007 were serotyped, with 84 (43.8 %) and 159 (82.8 %) isolates belonging to serotypes covered by the pneumococcal heptavalent conjugate and polysaccharide vaccines, respectively. All non-meningitis isolates were susceptible to penicillin, and the attributable mortality was 21.4 %. Patients who fulfilled the US Advisory Committee on Immunization Practices criteria for vaccination with the pneumococcal polysaccharide vaccine comprised 74.0 % of the study cohort and had a significantly higher mortality risk.

Abbreviations: ACIP, Advisory Committee on Immunization Practices; PCV7, heptavalent conjugate vaccine; PPV, 23-valent polysaccharide vaccine.




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[Abstract] [Full Text] [PDF]


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