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J Med Microbiol 57 (2008), 1036-1038; DOI: 10.1099/jmm.0.2008/000588-0
© 2008 Society for General Microbiology
ISSN 1473-5644

Case Report

Daptomycin non-susceptible meticillin-resistant Staphylococcus aureus USA 300 isolate

Madhukiran H. Murthy1, Michael E. Olson2, Robert W. Wickert2, Paul D. Fey2 and Ziba Jalali1

1 Department of Internal Medicine and Infectious Disease, University of Nebraska Medical Center, Omaha, USA

2 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, USA

Correspondence
Ziba Jalali
zjalali{at}unmc.edu

Received 20 January 2008
Accepted 9 April 2008

Daptomycin is a novel bactericidal agent active against Gram-positive pathogens including meticillin-resistant Staphylococcus aureus (MRSA). Our case is unique in the description of an MRSA USA 300 isolate that developed decreased susceptibility to daptomycin during daptomycin and vancomycin therapy. Directed sequencing detected a previously reported mutation in mprF, resulting in a T345A substitution, associated with non-susceptibility to daptomycin.

Abbreviations: MRSA, meticillin-resistant Staphylococcus aureus.




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