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J Med Microbiol 57 (2008), 851-855; DOI: 10.1099/jmm.0.47823-0
© 2008 Society for General Microbiology
ISSN 1473-5644

Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli

Minna Hannula and Marja-Liisa Hänninen

Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland

Correspondence
Minna Hannula
minna.hannula{at}helsinki.fi

Received 13 December 2007
Accepted 29 February 2008

The CmeABC efflux pump plays an important role in the antimicrobial resistance of Campylobacter jejuni and Campylobacter coli. The aim of this investigation was to study the effect of putative efflux pump inhibitors, phenyl-arginine-β-naphthylamide (PAβN) and 1-(1-naphthylmethyl)-piperazine (NMP), as well as the effect of putative efflux pump inducers, sodium salicylate and sodium deoxycholate, on the MIC levels of erythromycin, ciprofloxacin, kanamycin, tetracycline and rifampicin for C. jejuni and C. coli. Our results indicated that susceptibility to erythromycin and rifampicin increased, respectively, 8- to 32- and 8- to 64-fold in the presence of PAβN and to a lesser extent in the presence of NMP. Salicylate produced a 2- to 4-fold increase in ciprofloxacin MIC values, whereas little effect was observed in the presence of deoxycholate.

Abbreviations: EPI, efflux pump inhibitor; NMP, 1-(1-naphthylmethyl)-piperazine; PAβN, phenyl-arginine-β-naphthylamide; RND, resistance–nodulation–cell division.






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