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J Med Microbiol 57 (2008), 809-813; DOI: 10.1099/jmm.0.47802-0
© 2008 Society for General Microbiology
ISSN 1473-5644

Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system

Allison Adonizio1, Sixto M. Leal, Jr1, Frederick M. Ausubel3 and Kalai Mathee1,2

1 Department of Biological Sciences, College of Arts and Sciences, Florida International University, Miami, FL 33199, USA

2 Department of Molecular Microbiology and Immunology, College of Medicine, Florida International University, Miami, FL 33199, USA

3 Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA

Correspondence
Kalai Mathee
Kalai.Mathee{at}fiu.edu

Received 7 December 2007
Accepted 19 March 2008

Expression of a myriad of virulence factors and innate antibiotic resistance enables the opportunistic human pathogen Pseudomonas aeruginosa to create intractable infections. Using a nematode model, we screened for novel inhibitors of this pathogen. Aqueous extracts of three plants, Conocarpus erectus, Callistemon viminalis and Bucida buceras, were examined for their effects on P. aeruginosa killing of the nematode Caenorhabditis elegans. The results were evaluated in toxin-based and infection-based assays using P. aeruginosa strains PAO1 and PA14. The tested plant extracts prevented mortality via gut infection in approximately 60 % of the worms and caused a 50–90 % reduction in death from toxin production. All extracts inhibited nematode death by P. aeruginosa without host toxicity, indicating their potential for further development as anti-infectives.

Abbreviations: QS, quorum sensing.






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