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J Med Microbiol 57 (2008), 428-431; DOI: 10.1099/jmm.0.47694-0
© 2008 Society for General Microbiology
ISSN 1473-5644

Balamuthia mandrillaris resistance to hostile conditions

Ruqaiyyah Siddiqui1, Antonio Ortega-Rivas2 and Naveed Ahmed Khan1

1 School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, UK

2 Department of Parasitology, La Laguna University, La Laguna, Canary Islands, Spain

Correspondence
Naveed Ahmed Khan
n.khan{at}sbc.bbk.ac.uk

Received 15 October 2007
Accepted 7 January 2008

The resistance of Balamuthia mandrillaris to physical, chemical and radiological conditions was tested. Following treatments, viability was determined by culturing amoebae on human brain microvascular endothelial cells for up to 12 days. B. mandrillaris cysts were resistant to repeated freeze–thawing (five times), temperatures of up to 70 °C, 0.5 % SDS, 25 p.p.m. chlorine, 10 µg pentamidine isethionate ml–1 and 200 mJ UV irradiation cm–2.

Abbreviations: HBMEC, human brain microvascular endothelial cell.






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