J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
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J Med Microbiol 57 (2008), 261-266; DOI: 10.1099/jmm.0.47237-0
© 2008 Society for General Microbiology
ISSN 1473-5644

Is lipopolysaccharide a factor in infectivity of Chlamydia trachomatis?

Sanaa Fadel and Adrian Eley

Henry Wellcome Laboratories for Medical Research, Unit of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK

Correspondence
Adrian Eley
a.r.eley{at}sheffield.ac.uk

Received 18 February 2007
Accepted 9 November 2007

Lipopolysaccharide (LPS) is a major surface component of Chlamydia trachomatis, as with all Gram-negative bacteria. The effect of C. trachomatis LPS on C. trachomatis infectivity of human epithelial cells was investigated. C. trachomatis LPS and C. trachomatis LPS antibody significantly reduced infectivity, mostly in a dose-dependent manner. As the structure of LPS in C. trachomatis is simple and consists only of lipid A and 3-deoxy-D-manno-octulosonic acid (Kdo), we investigated whether lipid A or Kdo was inhibitory to chlamydial infectivity. Polymyxin B, as a lipid A inhibitor, and Kdo considerably reduced C. trachomatis infectivity. With all the LPS inhibitors used, there was greater inhibition against serovar E than serovar LGV. These results suggest a role for LPS in chlamydial infectivity. Elucidation of how LPS acts in infectivity and identification of host-cell receptors would help in understanding pathogenicity.

Abbreviations: EB, elementary body; GAG, glycosaminoglycan; Kdo, 3-deoxy-D-manno-octulosonic acid; PmB, polymyxin B; TC, tissue culture.






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