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J Med Microbiol 57 (2008), 1581-1584; DOI: 10.1099/jmm.0.2008/001149-0
© 2008 Society for General Microbiology
ISSN 0022-2615

Case Report

Paecilomyces lilacinus peritonitis complicating peritoneal dialysis cured by oral voriconazole and terbinafine combination therapy

Brian Pin-Hsuan Chang1, Pei-Lun Sun2, Fu-Yuan Huang1,3, Tsuen-Chiuan Tsai4, Chun-Chen Lin1, Ming-Dar Lee1, Yee-Chun Chen5, Jin-Cherng Sheu6 and Jeng-Daw Tsai1,3

1 Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan

2 Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan

3 Department of Pediatrics, Taipei Medical University, Taipei, Taiwan

4 Department of Pediatrics, Taipei Medical University Wan-Fang Hospital, Taipei, Taiwan

5 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

6 Department of Pediatric Surgery, Mackay Memorial Hospital, Taipei, Taiwan

Correspondence
Jeng-Daw Tsai
tsaijd{at}yahoo.com.tw

Received February 11, 2008
Accepted August 14, 2008

Fungal peritonitis (FP) is a serious complication in patients on continuous ambulatory peritoneal dialysis (CAPD). We report a case of CAPD-related FP caused by Paecilomyces lilacinus in a 15-year-old uraemic boy. The infection was successfully treated by combination therapy consisting of oral voriconazole and terbinafine, which has not been previously reported in the treatment of FP.

Abbreviations: CAPD, continuous ambulatory peritoneal dialysis; CRP, C-reactive protein; CT, computed tomography; FP, fungal peritonitis; WBC, white blood cell.

The GenBank/EMBL/DDBJ accession number for the rDNA sequence of Paecilomyces lilacinus is EU306174.






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