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Antimicrobial susceptibility testing of Bordetella pertussis in Taiwan prompted by a case of pertussis in a paediatric patient

¹ Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan, ROC

² Department of Life Sciences and Program in Genome Sciences, National Yang-Ming University, Taipei, Taiwan, ROC

³ Departments of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taoyuan, Taiwan, ROC

⁴ Center of General Education, National Taipei College of Nursing, Taipei, Taiwan, ROC

Correspondence
Chuen-Sheue Chiang
cschiang10{at}cdc.gov.tw

Received April 24, 2008
Accepted August 11, 2008

In Taiwan, pertussis is a notifiable disease with a low incidence in recent years, and antimicrobial susceptibility testing for the causative agent, Bordetella pertussis, has not been reported to date. In May 2007, the Centers for Disease Control, Taiwan, was informed of a 1-month-old pertussis patient who did not respond to erythromycin treatment. In this study, we report the result of antimicrobial susceptibility testing performed for the suspected erythromycin-resistant isolate, as well as for an additional 27 B. pertussis clinical isolates that represented almost all epidemiologically unrelated isolates obtained throughout Taiwan between 2003 and 2007. All isolates were fully susceptible to azithromycin, erythromycin, clarithromycin and trimethoprim/sulfamethoxazole (MIC 0.047 µg ml^–1). This result demonstrates the general susceptibility of B. pertussis to antimicrobial agents in vitro in Taiwan.