J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gur, D.
Right arrow Articles by Castanheira, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gur, D.
Right arrow Articles by Castanheira, M.
Agricola
Right arrow Articles by Gur, D.
Right arrow Articles by Castanheira, M.
J Med Microbiol 57 (2008), 1529-1532; DOI: 10.1099/jmm.0.2008/002469-0
© 2008 Society for General Microbiology
ISSN 0022-2615

Increasing carbapenem resistance due to the clonal dissemination of oxacillinase (OXA-23 and OXA-58)-producing Acinetobacter baumannii: report from the Turkish SENTRY Program sites

Deniz Gur1, Volken Korten2, Serhat Unal3, Lalitagauri M. Deshpande4 and Mariana Castanheira4

1 Hacettepe University, Children's Hospital, Ankara, Turkey

2 Marmara University Hospital, Istanbul, Turkey

3 Hacettepe University, School of Medicine, Infectious Disease Unit, Ankara, Turkey

4 JMI Laboratories, North Liberty, IA 52317, USA

Correspondence
Mariana Castanheira
mariana-castanheira{at}jmilabs.com

Received April 4, 2008
Accepted August 20, 2008

A significant increase in carbapenem-resistance rates among Acinetobacter baumannii isolates collected in two Turkish medical centres was detected in the 2000–2006 period (20–60 %) by the SENTRY Antimicrobial Surveillance Program. Carbapenem-resistant strains from 2006 were evaluated for the presence of encoding genes and epidemic clonality. OXA-58-like and OXA-23-like carbapenemase-producing strains were detected in both medical institutions. Seventeen out of 18 strains from Ankara were positive for blaOXA-58 primers and belonged to the same clone, whilst 26 isolates (25 from Istanbul and one from Ankara) harboured blaOXA-23-like genes and showed identical or similar PFGE patterns. Isolates producing OXA-23-like carbapenemases were more resistant than OXA-58-like carbapenemase producers to non-carbapenem antimicrobial agents. Carbapenem resistance in these institutions was observed to be largely driven by the dissemination of clones producing OXA-type carbapenemases.

Abbreviations: FDA, Food and Drug Administration; MβL, metallo-β-lactamase.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2008 Society for General Microbiology.