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J Med Microbiol 57 (2008), 1514-1517; DOI: 10.1099/jmm.0.2008/001636-0
© 2008 Society for General Microbiology
ISSN 0022-2615

Synergy of gatifloxacin with cefoperazone and cefoperazone–sulbactam against resistant strains of Pseudomonas aeruginosa

N. Sivagurunathan1,2, S. Krishnan2, J. Venkat Rao1, Anantha Naik Nagappa1, V. M. Subrahmanyam1 and B. Meenashi Vanathi3

1 Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India

2 Department of Pharmaceutical Biotechnology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, India

3 Department of Pharmaceutical Biotechnology, Shree Devi College of Pharmacy, Airport Road, Kenjar Village, Mangalore, Karnataka 574142, India

Correspondence
B. Meenashi Vanathi
meenashivanathi{at}gmail.com

Received March 1, 2008
Accepted August 20, 2008

Chequerboard and time–kill methods were used to compare the in vitro efficacies of the combinations gatifloxacin (GAT) with cefoperazone (CFP) and GAT with cefoperazone–sulbactam (CFP-SUL) against 58 clinical isolates of Pseudomonas aeruginosa. The combinations GAT+CFP and GAT+CFP-SUL were shown to be synergistic for 36.2 and 58.6 % of isolates tested, respectively, using the chequerboard method. Time–kill studies with 11 strains showed synergy in 54.5 % for the GAT+CFP combination and 72.7 % for the GAT+CFP-SUL combination. The agreement between these two methods was found to be 72–81 %. There was a significant difference in synergy between the two combinations tested (P=0.011).

Abbreviations: CFP, cefoperazone; CFP-SUL, cefoperazone–sulbactam; FIC, fractional inhibitory concentration; GAT, gatifloxacin.






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