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J Med Microbiol 57 (2008), 1445-1453; DOI: 10.1099/jmm.0.2008/003160-0
© 2008 Society for General Microbiology
ISSN 0022-2615

Review

Helicobacter pylori virulence and the diversity of gastric cancer in Asia

Lam Tung Nguyen1,2, Tomohisa Uchida1,3, Kazunari Murakami2, Toshio Fujioka2 and Masatsugu Moriyama1

1 Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan

2 Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan

3 Department of Human Environmental and Social Medicine, Faculty of Medicine, Oita University, Oita 879-5593, Japan

Correspondence
Masatsugu Moriyama
mmoriyam{at}med.oita-u.ac.jp


Infection with cagPAI positive strains of Helicobacter pylori is recognized as being associated with an increased risk of gastric cancer. This article reviews the current knowledge on the structures and pathological functions of cagPAI and the CagA protein, focusing especially on the molecular mechanism through which CagA may be involved in gastric carcinogenesis. The possible link between the geographical distribution of cagPAI and cagA variations and gastric cancer diversity in Asia is also discussed.




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