J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kumar, S.
Right arrow Articles by Berry, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kumar, S.
Right arrow Articles by Berry, N.
Agricola
Right arrow Articles by Kumar, S.
Right arrow Articles by Berry, N.
J Med Microbiol 57 (2008), 1247-1250; DOI: 10.1099/jmm.0.2008/001719-0
© 2008 Society for General Microbiology
ISSN 1473-5644

Rising prevalence of enteric fever due to multidrug-resistant Salmonella: an epidemiological study

Surinder Kumar, Meher Rizvi{dagger} and Nidhika Berry

Department of Microbiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, India

Correspondence
Meher Rizvi
rizvimeher{at}yahoo.co.in

Received 11 March 2008
Accepted 17 June 2008

A prospective study of the prevalent aetiology of enteric fever was undertaken at a tertiary care hospital in North India at intervals of every 3 years. Salmonella spp. were isolated from 174 (7 %) patients. Amongst these, 140 (80 %) patients were infected by Salmonella enterica subspecies enterica serovar Typhi (S. Typhi) and 16 (9 %) by S. enterica serovar Paratyphi A; the remaining 11 % were infected by other S. enterica serogroups, Typhimurium, Paratyphi C and Senftenberg, and other group E salmonella. A significantly greater number of S. Typhi were isolated in the summer and monsoon months. Multidrug resistance (resistance to chloramphenicol, ampicillin and co-trimoxazole) sequentially increased from 34 % in 1999 to 66 % in 2005. Increasing resistance was also noticed to the other antibiotics, especially to the cephalosporins. Moreover 8 % of the S. Typhi isolates were found to be presumptive extended spectrum β-lactamase producers. There was a gradual development of resistance to fluoroquinolones over the 7 years. No resistance was observed to fluoroquinolones in 1999, while in 2005 4.4 % resistance was observed to sparfloxacin, 8.8 % resistance to ofloxacin and a high resistance, 13 %, to ciprofloxacin. This is an alarming development and it is of paramount importance to limit unnecessary use of fluoroquinolones and third generation cephalosporins so that their efficacy against salmonella is not jeopardized further.

Abbreviations: ESBL, extended spectrum β-lactamase.

{dagger}Present address: Department of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India.




This article has been cited by other articles:


Home page
 J Public Health (Oxf)Home page
E. I. Broughton, M. Ip, C. L. Coles, and D. G. Walker
Higher hospital costs and lengths of stay associated with quinolone-resistant Salmonella enterica infections in Hong Kong
J. Public Health Med., June 14, 2009; (2009) fdp057v1.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2008 Society for General Microbiology.