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J Med Microbiol 56 (2007), 1076-1080; DOI: 10.1099/jmm.0.47206-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Dissemination of imipenem-resistant Acinetobacter baumannii strains carrying the ISAba1–blaOXA-23 genes in a Chinese hospital

Hua Zhou, Bo-Rui Pi, Qing Yang, Yun-Song Yu, Ya-Gang Chen, Lan-Juan Li and Shu-Sen Zheng

The Key Laboratory of Infectious Disease of the Public Health Ministry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China

Correspondence
Yun-Song Yu
yvys119{at}163.com

Received 2 February 2007
Accepted 2 April 2007

An outbreak of 95 clinical infections with imipenem-resistant Acinetobacter baumannii in a Chinese hospital was investigated and the carbapenemase-encoding genes and their relationship with ISAba1 of these and a further 16 isolates recovered from the intensive care unit (ICU) environment were analysed. Almost all isolates were resistant to a wide range of antimicrobials; the lowest resistance rates were found for polymyxin E (17.1 %), cefoperazone/sulbactam (30.6 %) and ampicillin/sulbactam (67.6 %). Six pattern types defined by DNA macrorestriction patterns were distinguished among the clinical isolates with dissemination of pattern A (50 isolates) to patients in seven hospital units and pattern B (35 isolates) to eight units; the environmental isolates from ICUs were also of pattern A. All isolates were positive for the blaOXA-66 and blaOXA-23 genes. The OXA-23-encoding gene was located 34 bp downstream of ISAba1. No plasmids were detected and conjugal transfer of resistance was not demonstrated. The blaOXA-23 probe hybridized with 200 and 220 kb ApaI chromosomal fragments for type patterns A and B, respectively.

Abbreviations: ICU, intensive care unit.

The GenBank/EMBL/DDBJ accession number for the ISAba1–OXA-23 sequence reported in this work is DQ923478.




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