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J Med Microbiol 56 (2007), 1042-1046; DOI: 10.1099/jmm.0.47029-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Epigallocatechin gallate suppresses expression of receptor activator of NF-{kappa}B ligand (RANKL) in Staphylococcus aureus infection in osteoblast-like NRG cells

Ikuo Ishida1,2, Chikara Kohda1, Yoko Yanagawa1, Hideyo Miyaoka2 and Tadakatsu Shimamura1

1 Department of Microbiology and Immunology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

2 Department of Orthopedic Surgery, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

Correspondence
Ikuo Ishida
ikuo-i29{at}sea.plala.or.jp

Received 26 October 2006
Accepted 25 March 2007

Catechin, a constituent of tea, possesses various bioactivities. In particular, the most abundant catechin in tea is epigallocatechin gallate (EGCg), which has an anti-inflammatory effect. In the present study, the usability of EGCg for osteomyelitis treatment was examined. Osteomyelitis is a difficult disease to cure, partly due to bone lysis caused by infected osteoblasts. Since bone lysis is promoted by proinflammatory cytokines and the receptor activator of NF-{kappa}B ligand (RANKL), osteoblasts were infected with Staphylococcus aureus and the effect of EGCg on the production of cytokines was examined. It was found that the production of interleukin 6 and RANKL was suppressed in the osteoblasts treated with EGCg, which indicated an inflammation suppression effect of EGCg in osteomyelitis treatment.

Abbreviations: EGCg, epigallocatechin gallate; IL, interleukin; RANKL, receptor activator of NF-{kappa}B ligand; TLR, Toll-like receptor; TNF, tumour necrosis factor.






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