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J Med Microbiol 56 (2007), 937-939; DOI: 10.1099/jmm.0.46965-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Interpretive criteria to differentiate low- and high-level mupirocin resistance in Staphylococcus aureus

Naira Elane Moreira de Oliveira1, Ana Paula Couto Marques Cardozo1, Elizabeth de Andrade Marques2, Kátia Regina Netto dos Santos1 and Marcia Giambiagi deMarval1

1 Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, RJ, Brazil

2 Faculdade de Ciências Medicas, Universidade do Estado do Rio de Janeiro, RJ, Brazil

Correspondence
Marcia Giambiagi-deMarval
marciagm{at}micro.ufrj.br

Received 22 September 2006
Accepted 22 March 2007

Meticillin-resistant Staphylococcus aureus isolates were classified into three mupirocin susceptibility groups by the disc diffusion method using 5 and 200 µg mupirocin discs. The zone diameter observed for a 5 µg disc distinguished MupS from the resistant strains (either MupRL or MupRH). On the other hand, a 200 µg disc distinguished the high-resistance MupRH strains from the other two (MupS or MupRL). Thus, the concomitant use of 5 and 200 µg mupirocin discs allowed the clear distinction among the three mupirocin susceptibility groups, MupS, MupRL or MupRH.

Abbreviations: MRSA, meticillin-resistant Staphylococcus aureus.




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X. Malaviolle, C. Nonhoff, O. Denis, S. Rottiers, and M. J. Struelens
Evaluation of disc diffusion methods and Vitek 2 automated system for testing susceptibility to mupirocin in Staphylococcus aureus
J. Antimicrob. Chemother., November 1, 2008; 62(5): 1018 - 1023.
[Abstract] [Full Text] [PDF]


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