J Med Microbiol NEW Faster Access
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wells, C. L.
Right arrow Articles by Bendel, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wells, C. L.
Right arrow Articles by Bendel, C. M.
Agricola
Right arrow Articles by Wells, C. L.
Right arrow Articles by Bendel, C. M.
J Med Microbiol 56 (2007), 688-693; DOI: 10.1099/jmm.0.47049-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Candida glabrata colonizes but does not often disseminate from the mouse caecum

Carol L. Wells1,2, Mary-Alice Johnson3,{dagger}, Michelle J. Henry-Stanley1 and Catherine M. Bendel3

1 Department of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN 55455-0374, USA

2 Department of Surgery, University of Minnesota, Minneapolis, MN 55455-0374, USA

3 Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455-0374, USA

Correspondence
Carol L. Wells
wells002{at}umn.edu

Received 2 November 2006
Accepted 30 January 2007

Candida glabrata is the second or third most frequent cause of candidaemia. The gastrointestinal tract is considered to be a major portal of entry for systemic candidiasis, but relatively few studies have investigated the pathogenesis of C. glabrata. Experiments were designed to clarify the ability of C. glabrata to disseminate from the mouse intestinal tract. Following oral inoculation, C. glabrata readily colonized the caeca [approx. 107 cells (g caecum)–1] of antibiotic-treated mice, but extraintestinal dissemination was not detected. Superimposing several mouse models of trauma and/or immunosuppression known to induce dissemination of Candida albicans and other intestinal microbes did not cause C. glabrata to disseminate often, although one exception was mice given high doses of dexamethasone for 4 days. These data support the hypothesis that the antibiotic-treated mouse intestine may be an epidemiological reservoir for C. glabrata and that this yeast tends to disseminate under specific clinical conditions.

Abbreviations: i.p., intraperitoneally; MLNs, mesenteric lymph nodes.

{dagger}Present address: Alaska Neonatology Assoc. Inc., 3340 Providence Drive #366, Anchorage, AK 99508, USA.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2007 Society for General Microbiology.