J Med Microbiol NEW Faster Access
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pisa, D.
Right arrow Articles by Carrasco, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pisa, D.
Right arrow Articles by Carrasco, L.
Agricola
Right arrow Articles by Pisa, D.
Right arrow Articles by Carrasco, L.
J Med Microbiol 56 (2007), 571-578; DOI: 10.1099/jmm.0.47042-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Evolution of antibody response and fungal antigens in the serum of a patient infected with Candida famata

Diana Pisa, Marta Ramos, Susana Molina, Patricia García and Luis Carrasco

Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Cantoblanco, 28049 Madrid, Spain

Correspondence
Luis Carrasco
lcarrasco{at}cbm.uam.es

Received 31 October 2006
Accepted 25 January 2007

The presence of fungal antibodies and antigens in the serum of a patient diagnosed in 1996 with acute zonal occult outer retinopathy caused by Candida famata infection was examined. Antibodies against C. famata increased until 1999–2000 when antifungal treatment was initiated. The antibodies were detected by ELISA and immunofluorescence analysis using C. famata. These antibodies were not immunoreactive against several Candida species tested. Positive immunofluorescence was obtained with IgM, but not IgA, IgG or IgE. Moreover, the IgM response disappeared several months after treatment with antifungal compounds, despite the fact that C. famata antigens were present in the blood. Finally, a sensitive test was developed to assay for the presence of C. famata antigens in serum based on the immunodetection of fungal antigens transferred to a nitrocellulose membrane and incubated with rabbit antibodies raised against C. famata. According to this method, the infection diminished with antifungal treatment.

Abbreviations: AZOOR, acute zonal occult outer retinopathy.




This article has been cited by other articles:


Home page
 J. Clin. Microbiol.Home page
D. Pisa, M. Ramos, P. Garcia, R. Escoto, R. Barraquer, S. Molina, and L. Carrasco
Fungal Infection in Patients with Serpiginous Choroiditis or Acute Zonal Occult Outer Retinopathy
J. Clin. Microbiol., January 1, 2008; 46(1): 130 - 135.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2007 Society for General Microbiology.