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J Med Microbiol 56 (2007), 454-458; DOI: 10.1099/jmm.0.46983-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant

Ryan H. Senaratne1, Joseph D. Mougous2, J. Rachel Reader3, Spencer J. Williams2,{dagger}, Tianjiao Zhang1, Carolyn R. Bertozzi2,4,5 and Lee W. Riley1

1 School of Public Health, University of California, Berkeley, CA 94720, USA

2 Department of Chemistry, University of California, Berkeley, CA 94720, USA

3 Comparative Pathology Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA

4 Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA

5 Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA

Correspondence
Carolyn R. Bertozzi
crb{at}berkeley.edu
Lee W. Riley
lwriley{at}berkeley.edu

Received 4 October 2006
Accepted 21 November 2006

The emergence of drug-resistant Mycobacterium tuberculosis strains and the widespread occurrence of AIDS demand newer and more efficient control of tuberculosis. The protective efficacy of the current Mycobacterium bovis bacille Calmette–Guérin (BCG) vaccine is highly variable. Therefore, development of an effective new vaccine has gained momentum in recent years. Recently, several M. tuberculosis mutants were tested as potential vaccine candidates in the mouse model of tuberculosis. However, only some of these mutants were able to generate protection equivalent to that of BCG in mice. This study reports the vaccine potential of an attenuated 5'-adenosine phosphosulfate reductase mutant ({Delta}cysH) of M. tuberculosis. Immunization of mice with either BCG or {Delta}cysH followed by infection with the virulent M. tuberculosis Erdman strain demonstrated that {Delta}cysH can generate protection equivalent to that of the BCG vaccine.

Abbreviations: BCG, bacille Calmette–Guérin; H&E, haematoxylin and eosin; p.i., post-infection; TB, tuberculosis.

{dagger}Present address: School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, Victoria 3010, Australia.






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