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J Med Microbiol 56 (2007), 376-379; DOI: 10.1099/jmm.0.46950-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Evolving EMRSA-15 epidemic in Singapore hospitals

Li-Yang Hsu1, Nidhi Loomba-Chlebicka2, Yin-Ling Koh2, Thean-Yen Tan3, Prabha Krishnan4, Raymond Tzer-Pin Lin5, Nancy Wen-Sin Tee6, Dale Andrew Fisher1 and Tse-Hsien Koh2

1 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore

2 Singapore General Hospital, Singapore

3 Changi General Hospital, Singapore

4 Tan Tock Seng Hospital, Singapore

5 National University Hospital, Singapore

6 Kandang Kerbau Women's and Children's Hospital, Singapore

Correspondence
Li-Yang Hsu
liyang_hsu{at}yahoo.com

Received 16 September 2006
Accepted 30 October 2006

The aim of this study was to determine the extent of EMRSA-15 spread in hospitals in Singapore. Molecular analysis of 197 non-duplicate meticillin-resistant Staphylococcus aureus (MRSA) isolates collected from five acute care public hospitals in Singapore in May 2005 revealed that 66 (33.5 %) were EMRSA-15 while 121 (61.4 %) belonged to the endemic multidrug-resistant ST239 clone. Median and mode vancomycin MIC for both major clones of health-care-associated MRSA were relatively high at 2.0 µg ml–1. Subsequent laboratory surveillance data collected from the first half of 2006 confirmed increasing numbers of the EMRSA-15 clone – ranging from 25.0 to 66.1 % of all MRSA isolated in local hospitals – replacing the ST239 clone island-wide.

Abbreviations: HA-MRSA, health-care-associated meticillin-resistant Staphylococcus aureus; MLST, multilocus sequence typing; MLVA, multilocus variable-number tandem-repeat analysis; MRSA, meticillin-resistant Staphylococcus aureus; SGH, Singapore General Hospital.




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