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J Med Microbiol 56 (2007), 352-359; DOI: 10.1099/jmm.0.46525-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Saccharomyces cerevisiae strain 905 reduces the translocation of Salmonella enterica serotype Typhimurium and stimulates the immune system in gnotobiotic and conventional mice

Flaviano S. Martins1,2,3, Ana Cristina P. Rodrigues4, Fabiana C. P. Tiago1, Francisco J. Penna2, Carlos A. Rosa1, Rosa M. E. Arantes5, Regina M. D. Nardi1, Maria J. Neves3 and Jacques R. Nicoli1

1 Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, C.P. 486, 30161-970, Belo Horizonte, MG, Brazil

2 Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais, C.P. 486, 30161-970, Belo Horizonte, MG, Brazil

3 Centro de Desenvolvimento da Tecnologia Nuclear/Comissão Nacional de Energia Nuclear (CDTN/CNEN), Belo Horizonte, MG, Brazil

4 Faculdade de Medicina, UNIFENAS, Belo Horizonte, MG, Brazil

5 Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, C.P. 486, 30161-970, Belo Horizonte, MG, Brazil

Correspondence
Jacques R. Nicoli
jnicoli{at}icb.ufmg.br

Received 16 January 2006
Accepted 2 November 2006

Previous results in the laboratory of the authors showed that Saccharomyces cerevisiae strain 905, isolated during ‘cachaça’ production, was able to colonize and survive in the gastrointestinal tract of germ-free and conventional mice, and to protect these animals against oral challenge with Salmonella enterica serotype Typhimurium or Clostridium difficile. In the present work, the effects of S. cerevisiae 905 on the translocation of Salm. Typhimurium (mesenteric lymph nodes, Peyer's patches, spleen, liver) as well as on the immune system (number of Küpffer cells, immunoglobulin production, clearance of Escherichia coli B41) were evaluated in gnotobiotic and/or conventional mice. The treatment with the yeast reduced significantly the translocation of Salm. Typhimurium to liver in gnotobiotic animals and to all the organs tested in conventional mice. The number of Küpffer cells per 100 hepatocytes in liver was significantly higher (P<0.05) in yeast mono-associated mice (52.9±15.7) than in germ-free controls (38.1±9.0). Probably as a consequence, clearance of E. coli B41 from the bloodstream was more efficient in yeast mono-associated animals when compared to germ-free mice. Higher levels (P<0.05) of secretory IgA in intestinal content and of IgA and IgM in serum were observed in yeast mono-associated mice when compared to germ-free group. Concluding, the protection against pathogenic bacteria observed in a previous study was probably due to a modulation of both local and systemic immunity of mice treated with S. cerevisiae 905.

Abbreviations: sIgA, secretory IgA.






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