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J Med Microbiol 56 (2007), 1700-1703; DOI: 10.1099/jmm.0.47482-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Case Report

A UK clinical isolate of Bordetella hinzii from a patient with myelodysplastic syndrome

Norman K. Fry1, John Duncan1, Martin T. Edwards1,2, Rebecca E. Tilley3, Dipti Chitnavis3, Ruth Harman3, Haydn Hammerton3 and Linda Dainton3

1 Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK

2 Statistics, Modelling and Bioinformatics Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK

3 West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, Suffolk IP33 2QZ, UK

Correspondence
Norman K. Fry
norman.fry{at}hpa.org.uk

Received 29 June 2007
Accepted 29 August 2007

What is believed to be the first clinical isolate of Bordetella hinzii in the UK, from a patient with myelodysplastic syndrome, is described. This patient had no known avian exposure, and the source of the organism remains unknown. It appears that the underlying immune deficiency of the patient increased the susceptibility to opportunistic infection with this organism. Human infection with B. hinzii is rare and this species is difficult to differentiate from Bordetella avium by routine phenotypic methods. Confirmation can be reliably achieved using genotypic methods, and the greater mutational variation of the ompA gene compared to other genes (e.g. 16S rRNA gene) allows unambiguous identification of this and other non-classical Bordetella species.

Abbreviations: RSIL, Respiratory and Systemic Infection Laboratory.

The GenBank/EMBL/DDBJ accession numbers for the Bordetella sequences reported in this paper are AM748263–AM748269.






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