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J Med Microbiol 56 (2007), 1692-1695; DOI: 10.1099/jmm.0.47286-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Case Report

Successful treatment of multi-resistant Pseudomonas aeruginosa osteomyelitis after allogeneic bone marrow transplantation with a combination of colistin and tigecycline

Marta Stanzani1, Fabio Tumietto2, Maria Benedetta Giannini1, Giuseppe Bianchi3, Anna Nanetti4, Nicola Vianelli1, Mario Arpinati1, Maddalena Giovannini1, Francesca Bonifazi1, Giuseppe Bandini1 and Michele Baccarani1

1 Institute of Hematology and Clinical Oncology ‘Lorenzo e Ariosto Serágnoli’, S. Orsola-Malpighi Hospital, University of Bologna, Italy

2 Division of Infectious Diseases, S. Orsola-Malpighi Hospital, University of Bologna, Italy

3 Rizzoli Orthopaedic Institutes, 5th Division, University of Bologna, Italy

4 Department of Clinical and Experimental Medicine, Section of Microbiology S. Orsola-Malpighi Hospital, University of Bologna, Italy

Correspondence
Marta Stanzani
marta.stanzani2{at}unibo.it

Received 12 March 2007
Accepted 10 August 2007

A case of osteomyelitis caused by multidrug-resistant Pseudomonas aeruginosa is reported in a patient who underwent allogeneic bone marrow transplantation for acute lymphoblastic leukaemia. The patient was successfully treated by prolonged administration of a full dose of colistin and tigecycline, and surgical curettage with the positioning of resorbable calcium sulfate pellets loaded with colistin.

Abbreviations: BCs, blood cultures; BMT, bone marrow transplantation; MRI, magnetic resonance imaging; MRPA, multidrug-resistant Pseudomonas aeruginosa.






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